BMS-986449
Catalog No: 25119
CAS Number:
Purity: 98% Min.
BMS-986449 is a CELMoD molecular glue that redirects the E3 ubiquitin ligase Cereblon to interact with and induce the degradation of Helios and Eos. It was optimized to induce rapid and deep degradation of Helios and Eos in primary Treg cells with selectivity over other CELMoD neosubstrates, as assessed by global proteomic analysis of primary T cells.
For research use only. We do not sell to patients.
Chemical Information
| Name | BMS-986449 |
|---|---|
| Iupac Chemical Name | (S)-3-((R)-5-(6-amino-4,5-dimethylpyridin-2-yl)-4-fluoro-3-methyl-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
| Synonyms | BMS-986449; BMS986449; BMS 986449 |
| Molecular Formula | C21H21FN4O3 |
| Molecular Weight | 396.41 |
| Smile | O=C1NC([C@@H](N2[C@H](C)C3=C(F)C(C4=CC(C)=C(C)C(N)=N4)=CC=C3C2=O)CC1)=O |
| InChiKey | CNRNDVOTRSDMEF-ABAIWWIYSA-N |
| InChi | InChI=1S/C21H21FN4O3/c1-9-8-14(24-19(23)10(9)2)12-4-5-13-17(18(12)22)11(3)26(21(13)29)15-6-7-16(27)25-20(15)28/h4-5,8,11,15H,6-7H2,1-3H3,(H2,23,24)(H,25,27,28)/t11-,15+/m1/s1 |
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| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
[1]. Barnes M J. Selective degradation of Helios induces Treg cell reprogramming and enhanced antitumor immunity[J]. Cancer Research, 2025, 85(8_Supplement_1): 2249-2249.
Chemical Structure
